"Looking for an overlooked film? A little something much better than it sounds? A film you might pass by on the video shelf because you've never heard how good it is? Then check out ISOLATION. Working from a rather inauspicious premise (a genetic experiment on an Irish cow farm creates a killer mutant calf), writer-director Billy O'Brien conjures a remarkable genre achievement: a somber, sad, and absolutely convincing film that is also genuinely terrifying. ISOLATION is a wonderful example of the heights that the genre can achieve when the material is treated with absolute conviction and human sympathy, instead of the gleeful gore that mars too many modern efforts." - Steve Biodrowski, Cinefantastique